A comprehensive investigation into the long-term efficacy and safety of Fuyang Guben (supporting yang and consolidating root) acupuncture-moxibustion treatment for perennial allergic rhinitis (PAR), and exploring its underlying functional mechanisms.
A randomized trial divided patients exhibiting PAR into two cohorts: one receiving acupuncture alongside conventional Western medicine.
The 30 and western medicine group (collectively),
This JSON schema, containing a list of sentences, is to be returned. In the realm of Western medicine, fluticasone propionate nasal spray was administered, one spray into each nasal passage, once daily, for a duration of six weeks. In conjunction with the western medicine group's treatment, fuyangguben acupuncture-moxibustion therapy was further applied. Warm needling of Dazhui (GV14) accompanied acupuncture treatments on Shangxing (GV23), Yintang (GV24+), bilateral Yingxiang (LI20), Shangyingxiang (EX-HN8), Sibai (ST2), Hegu (LI4), and Chize (LU5). For the first four weeks, participants in this cohort received acupuncture-moxibustion therapy for 30 minutes, three times a week. The final two weeks reduced the frequency to two sessions per week, concluding a six-week treatment course. Comparing the reflective total nasal symptom score (rTNSS), the total non-nasal symptom score (TNNSS), the total ophthalmic symptom score (TOSS), and the rhinitis quality of life scale (RQLQ) was performed in each treatment group at pre-treatment, post-treatment, and at follow-up visits at 10, 18, and 30 weeks respectively. Employing ELISA methodology, the serum levels of total immunoglobulin E (IgE) and interleukin-4 (IL-4) were ascertained before and after the treatment regimen.
Post-treatment, the rTNSS, TNNSS, TOSS, and RQLQ scores were observed to be lower than their respective pre-treatment values for every group.
In each group, the rTNSS, TNNSS, TOSS, and RQLQ scores observed during follow-up visits in weeks 10, 18, and 30 were diminished compared to the pre-treatment values.
The acupuncture-integrated Western medicine group saw significantly lower scores than the Western medicine group, as documented in the data (005).
The supplied sentences have been rephrased ten times, presenting structurally unique alternatives. Each rewritten sentence provides an alternate way to articulate the same content. The acupuncture and western medicine group exhibited a substantial decrease in serum total IgE and IL-4 concentrations after treatment, contrasting with their levels before treatment.
Indicator values in the acupuncture and Western medicine cohort were found to be lower than in the Western medicine cohort alone, as indicated by data point 005.
<005).
Fuyang Guben acupuncture-moxibustion therapy, in conjunction with fluticasone propionate nasal spray, demonstrates a remarkably sustained efficacy for PAR, proving both safe and effective. The mode of action could stem from the downregulation of total serum IgE and serum interleukin-4.
Fuyang Guben acupuncture-moxibustion therapy, used alongside fluticasone propionate nasal spray for PAR treatment, presents a remarkably prolonged effect, proving safe and effective over time. Serum levels of total IgE and IL-4 could potentially be diminished, contributing to the operational mechanism.
In rats with lumbar disc herniation (LDH), the impact of acupuncture at Houxi (SI3) and Huantiao (GB30) on high mobility group box 1 (HMGB1) protein and mRNA levels in the spinal nerve trunk (SNT) was examined to understand the underlying mechanisms in LDH treatment using this paired-point acupuncture approach.
Eight rats each, randomly assigned to sham operation, model, conventional acupuncture (CA), and paired points (PP) groups, constituted the Sprague-Dawley (SD) rat sample. By injecting autologous suspension derived from a rat's nucleus pulposus, the LDH model was successfully established within the epidural space. For 14 consecutive days, rats in the CA group received daily acupuncture at bilateral Weizhong (BL40), Dachangshu (BL25), and Shenshu (BL23) acupoints, whereas the PP group's regimen involved acupuncture at bilateral SI3 and GB30 acupoints, each lasting 30 minutes. A thermal pain stimulator was utilized to identify the thermal pain tolerance of the rats' hind feet, both sides included. Rat serum samples were analyzed using ELISA to quantify the levels of IL-1, IL-6, and IL-8. local intestinal immunity The rat lumbar (L)5 SNT samples were analyzed for HMGB1 protein expression through the utilization of Western blot and immunofluorescence. Employing qPCR, the relative expression of HMGB1 mRNA in L5 SNT specimens was determined. A study of the morphological changes in L5 SNT was conducted using HE staining.
In contrast to the sham-operated group, the model group exhibited a diminished thermal pain threshold in both hind feet.
As compared to the model group, the bilateral hind feet of the CA and PP groups displayed enhanced thermal pain thresholds.
This sentence, despite its resemblance to the original statement, exhibits an altered structure, presenting a contrasting viewpoint. The model group rats demonstrated a notable increase in both HMGB1 protein and mRNA expression in the L5 SNT, along with elevated serum levels of interleukins IL-1, IL-6, and IL-8.
<0000 1,
Unlike the subjects receiving a deceptive procedure, Decreases were observed in the HMGB1 protein and mRNA expressions in L5 SNT, and concurrent declines in serum concentrations of IL-1, IL-6, and IL-8 were noted.
<001,
<0000 1,
<0001,
The <005> in the CA and PP cohorts differed from the values seen in the model group. The recovery of the indexed parameters in the PP group was considerably more marked than that observed in the CA group.
<005,
<0001,
<001,
The requested JSON schema format comprises a list of sentences. In the model group, histomorphological findings indicated a prevalence of scattered and various-sized nerve fibers, vacuolation, extensive disintegration of myelin sheaths, and degradation of Schwann cells. In the CA and PP groups, regularly-arranged nerve fibers were apparent, signifying myelin sheaths regeneration. The PP group experienced demonstrably more histopathological recovery than the CA group.
Acupuncture treatment suppresses the expression of HMGB1 protein and mRNA in rats subjected to LDH, thereby decreasing the production of IL-1, IL-6, and IL-8, ultimately contributing to the reduction of inflammation and pain. The therapeutic effect of the PP group is significantly more conspicuous than that of the CA group.
Acupuncture intervention in rats with LDH demonstrated a decrease in HMGB1 protein and mRNA expression, and a concomitant reduction in IL-1, IL-6, and IL-8 production, which promoted a beneficial effect on inflammation and pain. Agricultural biomass The PP group displays a more conspicuous therapeutic effect when compared to the CA group.
A study to ascertain the consequences of scalp cluster needling on nuclear factor kappa B p65 (NF-κB p65), NF-κB inhibitory protein (IKB), secretase 1 (BACE1), beta-amyloid protein (Aβ), and hippocampal morphology in AD rats, aiming to discover the mechanism behind its purported improvement in AD.
By random assignment, male Wistar rats were distributed into four groups of 12 each: sham operation, acupuncture, medication, and a control group. The AD model was a consequence of A1-42 being administered to both hippocampal regions. In the clustering acupuncture group, Baihui (DU20) and 1 millimeter to the left and right of DU20 were needled for 30 minutes, once daily, for 14 days. Rats in the medication cohort were given donepezil hydrochloride at a dosage of 0.5 milligrams per kilogram body weight.
d
Intragastric perfusion is given once a day, continuing for 14 days. Cognitive function in rats was assessed using the standardized Morris water maze test. The structural changes of hippocampal tissue were visualized through the use of HE staining. Western blot analysis served to quantify the hippocampal expression levels of NF-κB p65, IκB, and BACE1. Selleck Torin 1 The ELISA technique served to identify the concentrations of A in the serum and hippocampus of rats.
In comparison to the sham operation group, the Morris water maze test's escape latency was extended in the model group, and the number of crossings to the original platform was reduced.
AD rat hippocampi displayed amplified protein expression of NF-κB p65 and BACE1, coupled with elevated concentrations of A in both the hippocampus and serum.
<001
The IKB protein's expression was lessened,
The JSON schema outputs a list of sentences. The clustering acupuncture and medication groups demonstrated a decrease in escape latency and an increase in the number of crossings over the original platform in the Morris water maze test, as compared to the model group.
<001
Hippocampal levels of A and serum levels of A, along with the protein expression of NF-κB p65 and BACE1, were reduced in the hippocampus.
<001
The IKB protein's expression experienced a rise,
Meticulously crafted, this JSON schema returns a list of sentences, each distinct. The protein expressions of NF-κB p65 and IκB were found to be lower in the clustering acupuncture group when compared with the medication group.
This JSON schema, with sentences in a list, is expected to be returned. Loose and disordered hippocampal cell organization was apparent in HE stains, characterized by hyperchromatic cytoplasm and pyknotic nuclei. Inflammatory cell infiltration was more severe in the model group, but less so in the clustering acupuncture and medication groups.
Cognitive dysfunction in AD rats may be mitigated by scalp-point cluster needling, which could decrease inflammatory cell infiltration within the hippocampus, thus affecting NF-κB p65, IκB, and BACE1 expression levels and suppressing Aβ aggregation.
In AD rat models, cluster needling at scalp points could potentially reverse cognitive impairment by reducing inflammation within the hippocampus, impacting the regulation of NF-κB p65, IκB, and BACE1 gene expression, and preventing amyloid-beta aggregation.
The objective is to understand how Huayu Tongluo (resolving blood stagnation to dredge meridian-collaterals) moxibustion affects remyelination and the Sonic Hedgehog (Shh) signaling pathway in the corpus callosum of vascular dementia (VD) rats, thereby uncovering the mechanism of VD improvement.